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zinc oxide nanoparticles articles

found that ZnO NPs with a crystal size of 20 nm resulted in a concentration-dependent loss of ovarian cancer SKOV3 cell viability [51]. Compared to constituent nanomaterials (nanocurcumin, PMMA-PEG, ZnO NPs, and PMMA-PEG/ZnO), the Cur/PMMA-PEG/ZnO nanocomposite performed largest observable inhibition on human gastric cancer AGS cell viability (IC50 ∼0.01 μg/mL−1) and induced cell cycle arrest at the S phase. Zinc oxide nanoparticles (ZnO NPs) also have remarkable optical, physical, and antimicrobial properties and therefore have great potential to enhance agriculture. In all cases the Ref. So we can believe that eluted Zn2+ from ZnO NPs also take a key role in antibacterial action. The particle sizes of zinc oxide nanoparticles were determined by AFM (AFM, SPM-9500J3, Shimadzu CO., Japan) and Zetasizer Nano-ZS90 (Malvern Instruments) by the method of Du et al. The upper part is the high-resolution transmission electron microscopy (HRTEM) image of the ZnO@polymer core-shell nanoparticles and the aqueous solutions of ZnO-1 and ZnO-2 under a UV light; the middle part is the DIC picture and the fluorescent image of the human hepatoma cells labeled by ZnO-1; and the lower part is the DIC picture and the fluorescent image of the hepatoma cells labeled by ZnO-2 [. Go to our fabricated ZnO NPs using the chemical precipitation method and further evaluated their anticancer activity [64], which found that ZnO NPs with different sizes could obviously inhibit the proliferation of fibrosarcoma HT1080 cells. XX is the XXth reference in the list of references. As far as method of formation is concerned, ZnO NPs can be synthesized by several chemical methods such as precipitation method, vapor transport method, and hydrothermal process. Recently, various approaches including physical, chemical and biological (“green chemistry”) have been used to prepare ZnO nanocomposites with different morphologies. It easily diffuses into the food material, kill the microbes, and prevent human being from falling ill. Aim: The authors report the biological synthesis of zinc oxide nanoparticles (ZnO‐NPs) from the petals extract of Rosa indica L. (rose). The XRD patterns and Raman spectra show that both synthesis routes lead to single-phase ZnO. Encouraging, HA/ZnO nanocomposite treatment for 72 hours did not cause toxicity to the normal human lung fibroblast (MRC-5) cell line. Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by the impairment of the skin-barrier functions, which was involved with complex interaction between genetic and environmental factors [112, 113]. Jiang et al. Tang et al. Therefore, ZnO NPs as a novel agent in order for zinc delivery have been developed and evaluated for their antidiabetic potential. Therefore, exposure to them is unavoidable, which makes it … or in a thesis or dissertation provided that the correct acknowledgement is given Using a simple sol-gel method, Xiong et al. Inflammation is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants [111]. The loss of the mitochondrial membrane potential could open outer membrane pores which would result in the release of some related apoptotic proteins including cytochrome c into the cytosol and activate the caspase. In addition, Phβ-GBP-ZnO NPs could alter cell membrane permeability and trigger high level of ROS formation both in S. aureus and P. vulgaris [87]. carried out a detailed study about ZnO NPs against Vibrio cholerae (two biotypes of cholera bacteria (classical and El Tor)). In addition, ZnO NPs have also been well known to promote the bioavailability of therapeutic drugs or biomolecules when functioning as drug carriers to achieve enhanced therapy efficiency. A broad variety of plant extract are used for the biosynthesis of ZnO NPs such as the leaf of Azadirachta indica (L.) [23], Cochlospermum religiosum (L.) [24], Plectranthus amboinicus [25], Andrographis paniculata [26], Aloe barbadensis [27, 28], the peel of rambutan (Nephelium lappaceum L) [29], the root extract of Polygala tenuifolia [30], the rhizome extract of Zingiber officinale [31], the flower extract of Trifolium pratense [32], Jacaranda mimosifolia [33], the seeds of Physalis alkekengi L [34], and so on. Copyright © 2018 Jinhuan Jiang et al. Green synthesis of zinc oxide nanoparticles using flower extract of Nyctanthes arbor-tristis and their antifungal activity. Interaction ZnO NPs with HT1080 cell has relatively higher ROS generation. ZnO NPs exhibit efficient blue emissions and near-UV emissions, which have green or yellow luminescence related to oxygen vacancies, therefore further extending its application into bioimaging field [12, 36, 120]. formally request permission using Copyright Clearance Center. The mitochondrial electron transport chain is known to be associated with intracellular ROS generation, and anticancer agents entering into cancer cells could destroy the electron transport chain and release huge amounts of ROS [58, 59]. investigated the regulatory mechanism of autophagy and the link between autophagy and ROS in ZnO NPs-treated lung epithelial cells [65]. Reproduced material should be attributed as follows: If the material has been adapted instead of reproduced from the original RSC publication RGD peptide-conjugated green fluorescent ZnO NWs can be specifically targeted to cell surface receptors in vitro [, P. K. Mishra, H. Mishra, A. Ekielski, S. Talegaonkar, and B. Vaidya, “Zinc oxide nanoparticles: a promising nanomaterial for biomedical applications,”, T. G. Smijs and S. Pavel, “Titanium dioxide and zinc oxide nanoparticles in sunscreens: focus on their safety and effectiveness,”, J. But recently, the antibacterial activity of ZnO NPs is still scarcely known. It found that ZnO NPs with small dimensions at higher doses (3 and 10 mg/kg) had a much greater antidiabetic effect compared to ZnSO4 (30 mg/kg). extracted crustacean immune molecule β-1,3-glucan binding protein (Phβ-GBP) from the heamolymph of Paratelphusa hydrodromus and then successfully fabricated the Phβ-GBP-coated ZnO NPs. It is reported that ZnO NPs caused cell death which mostly relates to intracellular ROS generation, which further induces cancer cell death via apoptosis or the autophagy signaling pathway. The ZnO NPs-induced apoptosis was mainly through both extrinsic and intrinsic apoptotic pathways, and some antiapoptotic genes of Bcl-2, AKT1, and JERK/2 were downregulated, while proapoptotic genes of p21, p53, JNK, and Bax were upregulated. We believe that nanomaterials would dramatically promote the development of medicine, and ZnO nanoparticles are expected to make more exciting contributions in these fields. The Food and Drug Administration (FDA) has recognized ZnO as safe due to its lack of or very weak dark toxicity in vitro and in vivo (Hu et al. Zinc oxide is known to protect the stomach and intestinal tract from damage by E. coli [ 65 ]. This perspective outlines the current state of knowledge concerning the interaction of zinc oxide nanoparticles with eukaryotic cells and the human body. Nanomedicine. Furthermore, it sheds light on the importance of zinc under physiological conditions. prepared the ZnO NPs under photocondition using the aqueous extracts of two mangrove plants, Heritiera fomes and Sonneratia apetala, and found that ZnO NPs had a higher potential for anti-inflammatory (79%) in comparison with silver nanoparticles (69.1%) [116]. Bai et al. Its efficacy was evaluated against two dermatophytes: namely: Trichophyton mentagrophytes and Microsporum canis which cause onychomycosis. Since the advent of nanoparticles and considering these biological activities of zinc ions, the anti-inflammatory effects of ZnO NPs have also attracted much attention. Hariharan et al. But up to now, the advanced anticancer mechanism study of ZnO NPs is still lacked of, especially in cellular and molecular mechanism strengthening. The important biomedical applications of zinc oxide nanoparticles are listed as below:- 1. The anticancer effects of ZnO NPs in different human cancer cell lines. If you are the author of this article you do not need to formally request permission The exact physical and chemical properties of zinc oxide nanoparticles depend on the different ways they are synthesized. The novel and affordable ceramic reinforcement that can be used effectively to increase the properties of … Zinc oxide nanoparticles (ZnO NPs), known for their chemical stability and strong adsorption, are used in everyday items such as cosmetics, sunscreens, and prophylactic drugs. The bulk zinc oxide (BZnO) groups were administered 5 mg/kg (BZnO-1) and 10 mg/kg (BZnO-2), correspondingly. The conjugated ZnO-RSW displayed 61.93% of inhibition in glucosidase while the bare ZnO NPs and RSW showed 21.48% and 5.90%, respectively. We are committed to sharing findings related to COVID-19 as quickly as possible. There are safety concerns related to Some other Gram-negative bacteria such as Pseudomonas aeruginosa (P. aeruginosa) [24, 79], Proteus vulgaris (P. vulgaris) [80], Vibrio cholerae (V. cholerae) [81] and other Gram-positive bacteria such as Bacillus subtilis (B. subtilis) [82] and Enterococcus faecalis (E. faecalis) [83] are also investigated. However, most studies have focused on their inhibitory actions on bacterial infections, and there is limited studies evaluating the interaction between ZnO-NPs and viruses. It showed that ZnO NPs with an average size about 30 nm caused cell death by directly contacting with the phospholipid bilayer of the membrane, destroying the membrane integrity. They have a large surface area relative to their size and high catalytic activity. This helps to place the in vivo behavior of zinc oxide nanoparticles in the proper context. The zinc oxide nanoparticle (ZnONP) groups received ZnONPs < 50 nm, specifically, 5 mg/kg (ZnONP-1) and 10 mg/kg (ZnONP-2). Moreover, Ohira and Yamamoto also found the antibacterial (E. coli and S. aureus) activity of ZnO NPs with small crystallite sizes was stronger than those with large crystallite sizes [97]. The antidiabetic activity was assessed with the help of α-amylase and α-glucosidase inhibition assay with murine pancreatic and small intestinal extracts [103]. ZnO NPs-exposed HepG2 cells presented higher cytotoxicity and genotoxicity, which were associated with cell apoptosis mediated by the ROS triggered mitochondrial pathway. Among metal nanoparticles, zinc oxide nanoparticles (ZnO-NPs) have been demonstrated to exert antimicrobial activities against various human pathogens [ 15 ]. Pardeshi and Patil synthesized ZnO NPs with different morphologies and crystallite sizes using this method by varying the calcination temperature from 400°C to 900°C. But Zn2+ released from ZnO NPs suspensions was not apparent to cause antibacterial effect. Fetching data from CrossRef. It was worth to note that these nanoparticles did not show any remarkable toxicity for human hepatoma cells when their concentrations were less than 0.2 mg/mL. The theory analysis and experimental research proved that ZnO NPs with less side effect present greater selectivity among normal and cancerous cells. ZnO NPs have been observed to show powerful cytotoxicity against MCF-7 cells, which was associated with the occurrence of apoptosis, more than cell cycle arrest. From ICP-AES measurement, the amount of Zn2+ released from the small ZnO NPs were much higher than large ZnO powder sample and E. coli was more sensitive to Zn2+ than S. aureus. Recently, nanomaterial-based nanomedicine, with high biocompatibility, easily surface functionalization, cancer targeting, and drug delivery capacity, has demonstrated the potential to overcome these side effects. Bell, D. G. Wingett, C. Hanley, and A. Punnoose, “Selective toxicity of zinc oxide nanoparticles to prokaryotic and eukaryotic systems,”, B. N. Singh, A. K. Rawat, W. Khan, A. H. Naqvi, and B. R. Singh, “Biosynthesis of stable antioxidant ZnO nanoparticles by, R. Ishwarya, B. Vaseeharan, S. Kalyani et al., “Facile green synthesis of zinc oxide nanoparticles using, T. Chatterjee, S. Chakraborti, P. Joshi, S. P. Singh, V. Gupta, and P. Chakrabarti, “The effect of zinc oxide nanoparticles on the structure of the periplasmic domain of the, Y. H. Hsueh, W. J. Ke, C. T. Hsieh, K. S. Lin, D. Y. Tzou, and C. L. Chiang, “ZnO nanoparticles affect, M. Divya, B. Vaseeharan, M. Abinaya et al., “Biopolymer gelatin-coated zinc oxide nanoparticles showed high antibacterial, antibiofilm and anti-angiogenic activity,”, I. Matai, A. Sachdev, P. Dubey, S. U. Kumar, B. Bhushan, and P. Gopinath, “Antibacterial activity and mechanism of Ag-ZnO nanocomposite on, S. Sarwar, S. Chakraborti, S. Bera, I. elucidated the efficiency of ZnO nanoparticles (NPs) against different cancer cell lines. As shown in Figure 3, within human hepatoma cells, ZnO-1 (derived from LiOH) with an average size of 3 nm showed green fluorescence, while ZnO-2 (derived from NaOH) with an average size of 4 nm appeared yellow. So, as a type of safe and cheap luminescent labels, the ZnO@polymer core-shell nanoparticles can be used as fluorescent probes for cell imaging in vitro [121]. The addition of radical scavengers such as mannitol, vitamin E, and glutathione could block the bactericidal action of ZnO NPs, potentially revealing that ROS production played a necessary function in the antibacterial properties of ZnO NPs. Authors contributing to RSC publications (journal articles, books or book chapters) Please enable JavaScript In addition, ZnO NPs-treated SKOV3 cells resulted in an upregulation of LC3-I/II and p53 expression, which further induced autophagic cell death. The solubility of Zn in Zn fertilizers plays an important role in the agronomic effectiveness of the fertilizer. The activity of antibiotics against the tested dermatophytes was enhanced, when evaluated in combination with … Zinc is a trace element and abundantly found mineral in all human tissues and tissue fluids. * P. Thatoi, R. G. Kerry, S. Gouda et al., “Photo-mediated green synthesis of silver and zinc oxide nanoparticles using aqueous extracts of two mangrove plant species, S. Yao, X. Feng, J. Lu et al., “Antibacterial activity and inflammation inhibition of ZnO nanoparticles embedded TiO, J. Q. Li, H. Q. Chen, B. Wang et al., “ZnO nanoparticles act as supportive therapy in DSS-induced ulcerative colitis in mice by maintaining gut homeostasis and activating Nrf2 signaling,”, T. Xia, W. Lai, M. Han, M. Han, X. Ma, and L. Zhang, “Dietary ZnO nanoparticles alters intestinal microbiota and inflammation response in weaned piglets,”, P. Zhu, Z. Weng, X. Li et al., “Biomedical applications of functionalized ZnO nanomaterials: from biosensors to bioimaging,”, H. M. Xiong, Y. Xu, Q. G. Ren, and Y. Y. Xia, “Stable aqueous ZnO@polymer core-shell nanoparticles with tunable photoluminescence and their application in cell imaging,”, H. Jiang, H. Wang, and X. Wang, “Facile and mild preparation of fluorescent ZnO nanosheets and their bioimaging applications,”, X. Tang, E. S. G. Choo, L. Li, J. Ding, and J. Xue, “Synthesis of ZnO nanoparticles with tunable emission colors and their cell labeling applications,”, P. Zhang and W. Liu, “ZnO QD@PMAA-co-PDMAEMA nonviral vector for plasmid DNA delivery and bioimaging,”, W. Wu, J. Shen, P. Banerjee, and S. Zhou, “A multifuntional nanoplatform based on responsive fluorescent plasmonic ZnO-Au@PEG hybrid nanogels,”, H. J. Zhang, H. M. Xiong, Q. G. Ren, Y. Y. Xia, and J. L. Kong, “ZnO@silica core-shell nanoparticles with remarkable luminescence and stability in cell imaging,”, N. H. Cho, T. C. Cheong, J. H. Min et al., “A multifunctional core–shell nanoparticle for dendritic cell-based cancer immunotherapy,”, K. Matsuyama, N. Ihsan, K. Irie, K. Mishima, T. Okuyama, and H. Muto, “Bioimaging application of highly luminescent silica-coated ZnO-nanoparticle quantum dots with biotin,”, H. Hong, J. Shi, Y. Yang et al., “Cancer-targeted optical imaging with fluorescent zinc oxide nanowires,”. The central attention is on the functionalization of the ZnO NPs surface with different kinds of biological molecules comprising different types of proteins, peptides, nucleic acids, folic acid, hyaluronan, and so on [47, 57, 71–73]. Puvvada et al. Corresponding authors, a Due to inherent toxicity of ZnO NPs, they possess strong inhibition effects against cancerous cell and bacteria, by inducing intracellular ROS generation and activating apoptotic signaling pathway, which makes ZnO NPs a potential candidate as anticancer and antibacterial agents. These results demonstrated that ZnO NPs with a small size had great effects on reducing skin inflammation in AD models. Sign up here as a reviewer to help fast-track new submissions. Abstract ZnO nanoparticles (ZnO NPs) have gained more attention in recent years due to their ability to induce the generation of reactive oxygen species (ROS) under light irradiation. You do not have JavaScript enabled. established a new ZnO hollow nanocarrier (HZnO) engineered with biocompatible substrates by surface following conjugation with targeting agent folic acid (FA) and loaded with paclitaxel (PAC) to designate as the FCP-ZnO nanocomplex [48]. "Reproduced from" can be substituted with "Adapted from". We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. The increasing focus on nano zinc oxide resulted in the invention and development of methods of nanoparticles synthesis. Zinc oxide nanoparticles (ZnO NPs) are used in an increasing number of industrial products such as rubber, paint, coating, and cosmetics. The solid was redispersed in 1 mL of water and centrifuged again. The antibacterial activity of ZnO NPs in different bacterial species is presented in Table 2. It appeared to increase the toxicity of the ZnO NPs to breast cancer MCF-7 and MDA-MB-231 cells at lower doses. Chandrasekaran and Pandurangan investigated the cytotoxicity of ZnO nanoparticles against cocultured C2C12 myoblastoma cancer cells and 3T3-L1 adipocytes, which showed that ZnO NPs could be more cytotoxic to C2C12 myoblastoma cancer cells than 3T3-L1 cells. ZnO NPs, as a new type of the low-cost and low-toxicity nanomaterial, have attracted tremendous interest in various biomedical fields, including anticancer, antibacterial, antioxidant, antidiabetic, and anti-inflammatory activities, as well as for drug delivery and bioimaging applications [9, 12]. the whole article in a third party publication with the exception of reproduction Based on its advanced intrinsic fluorescence, ZnO nanomaterial can also be used as a promising candidate for cell imaging and pathological studies. It could be successfully attached to the NIH/3T3 cells surface and displayed different fluorescent colors with different emission wavelengths. The main mechanism by which PEG-ZnO kills a cancer cell is by generating ROS and triggering p53-dependent apoptosis leading to cell death. Typical researches about biological imaging of ZnO NPs. described a straightforward, inexpensive, and ecofriendly ZnO NPs using the root extract of P. tenuifolia and the anti-inflammatory activities were investigated in LPS-stimulated RAW 264.7 macrophages [30]. Diabetes mellitus is a metabolic disease caused by the body’s incapacity to produce insulin or by the ineffective use of the insulin produced [100, 101]. Compared with bZnO, nZnO exerted higher anti-inflammatory properties by decreasing drastically on proinflammatory cytokines (IL-10, IL-13, IFN-γ, and Th2 cytokines) in the mouse model of AD. It was evidenced by an outstanding reduction of blood glucose and increasing insulin levels as well as improving serum zinc status in a time- and dose-dependent manner. Autophagy is a highly regulated catabolic process that activated in response to different kinds of stresses like damaged organelles, ROS, anticancer agents, and protein aggregation. By targeting the specific sites of cancer cells, nanoparticle-based drug delivery could reduce the overall amount of drugs used and thus minimize undesirable side effects [9, 66]. Hussein et al. Photo-triggered ROS generation by ZnO NPs and the resulting phototoxicity in cells have found use in antibacterial and anticancer applications. B. Moghaddam, M. Moniri, S. Azizi et al., “Eco-friendly formulated zinc oxide nanoparticles: induction of cell cycle arrest and apoptosis in the MCF-7 cancer cell line,”, J. Liu, X. Ma, S. Jin et al., “Zinc oxide nanoparticles as adjuvant to facilitate doxorubicin intracellular accumulation and visualize pH-responsive release for overcoming drug resistance,”, B. Zinc nanoparticles or zinc oxide nanoparticles of extremely low concentration cannot cause toxicity in human system. This research provided a novel insight into the regulation mechanisms of autophagy-lysosomes-mitochondria-ROS axis, which would contribute to a better understanding of the toxicity of nanomaterials. ZnO NPs prepared by this method exhibited strong potential for biomedical applications such as its excellent anticancer and antibacterial activity. De Angelis, F. Barone, A. Zijno et al., “Comparative study of ZnO and TiO, Y. Cao, M. Roursgaard, A. Kermanizadeh, S. Loft, and P. Moller, “Synergistic effects of zinc oxide nanoparticles and fatty acids on toxicity to Caco-2 cells,”, X. Fang, L. Jiang, Y. Gong, J. Li, L. Liu, and Y. Cao, “The presence of oleate stabilized ZnO nanoparticles (NPs) and reduced the toxicity of aged NPs to Caco-2 and HepG2 cells,”, J. Bai Aswathanarayan and R. Rai Vittal, “Muddegowda U: anticancer activity of metal nanoparticles and their peptide conjugates against human colon adenorectal carcinoma cells,”, V. Sharma, D. Anderson, and A. Dhawan, “Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2),”, M. J. Akhtar, M. Ahamed, S. Kumar, M. M. Khan, J. Ahmad, and S. A. Alrokayan, “Zinc oxide nanoparticles selectively induce apoptosis in human cancer cells through reactive oxygen species,”, Y. Deng and H. Zhang, “The synergistic effect and mechanism of doxorubicin-ZnO nanocomplexes as a multimodal agent integrating diverse anticancer therapeutics,”, A. Zinc oxide nanoparticles (ZnO-NPs) are widely used in almost every area of life. Zinc is well known to keep the structural integrity of insulin and has an active role in the secretion of insulin from pancreatic cells. We now gradually discover that the impact of zinc on the health of our body might be as far-reaching as that of iron. Epidemic disease cholera, a serious diarrheal disease caused by the intestinal infection of Gram-negative bacterium V. cholera, mainly affects populations in the developing countries [81, 94]. This perspective outlines the current state of knowledge concerning the interaction of zinc oxide nanoparticles with eukaryotic cells and the human body. ZnO NPs present certain cytotoxicity in cancer cells mainly by themselves based on a higher intracellular release of dissolved zinc ions, followed by increased ROS induction and induced cancer cell death via the apoptosis signaling pathway. Furthermore, the luminescence was very stable during cell culturing and the cells were alive at 45 min of exposure. Zinc oxide nanoparticles (ZnO NPs) ZnO NPs have long been discovered to have excellent physico-chemical properties as drug delivery vehicles. ZnO nanostructures were successfully attached onto or penetrated into the cells, which suggested that ZnO nanosheets with visible yellow-orange emission could act as a feasible label for the bioimaging. B. Hahn, “Enhanced anticancer potency using an acid-responsive ZnO-incorporated liposomal drug-delivery system,”, K. J. Bai, K. J. Chuang, C. M. Ma, T. Y. Chang, and H. C. Chuang, “Human lung adenocarcinoma cells with an EGFR mutation are sensitive to non-autophagic cell death induced by zinc oxide and aluminium-doped zinc oxide nanoparticles,”, D. P. Bai, X. F. Zhang, G. L. Zhang, Y. F. Huang, and S. Gurunathan, “Zinc oxide nanoparticles induce apoptosis and autophagy in human ovarian cancer cells,”, R. Hariharan, S. Senthilkumar, A. Suganthi, and M. Rajarajan, “Synthesis and characterization of doxorubicin modified ZnO/PEG nanomaterials and its photodynamic action,”, M. Pandurangan, G. Enkhtaivan, and D. H. Kim, “Anticancer studies of synthesized ZnO nanoparticles against human cervical carcinoma cells,”, R. Dhivya, J. Ranjani, J. Rajendhran, J. Mayandi, and J. Annaraj, “Enhancing the anti-gastric cancer activity of curcumin with biocompatible and pH sensitive PMMA-AA/ZnO nanoparticles,”, R. Dhivya, J. Ranjani, P. K. Bowen, J. Rajendhran, J. Mayandi, and J. Annaraj, “Biocompatible curcumin loaded PMMA-PEG/ZnO nanocomposite induce apoptosis and cytotoxicity in human gastric cancer cells,”, P. Patel, K. Kansara, V. A. Senapati, R. Shanker, A. Dhawan, and A. Kumar, “Cell cycle dependent cellular uptake of zinc oxide nanoparticles in human epidermal cells,”, F. Namvar, S. Azizi, H. S. Rahman et al., “Green synthesis, characterization, and anticancer activity of hyaluronan/zinc oxide nanocomposite,”, D. F. Stowe and A. K. S. Camara, “Mitochondrial reactive oxygen species production in excitable cells: modulators of mitochondrial and cell function,”, E. Moghimipour, M. Rezaei, Z. Ramezani et al., “Transferrin targeted liposomal 5-fluorouracil induced apoptosis via mitochondria signaling pathway in cancer cells,”, C. Y. Guo, L. Sun, X. P. Chen, and D. S. Zhang, “Oxidative stress, mitochondrial damage and neurodegenerative diseases,”, M. Chandrasekaran and M. Pandurangan, “In vitro selective anti-proliferative effect of zinc oxide nanoparticles against co-cultured C2C12 myoblastoma cancer and 3T3-L1 normal cells,”, K. N. Yu, T. J. Yoon, A. Minai-Tehrani et al., “Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation,”, S. Hackenberg, A. Scherzed, A. Gohla et al., “Nanoparticle-induced photocatalytic head and neck squamous cell carcinoma cell death is associated with autophagy,”, M. Arakha, J. Roy, P. S. Nayak, B. Mallick, and S. Jha, “Zinc oxide nanoparticle energy band gap reduction triggers the oxidative stress resulting into autophagy-mediated apoptotic cell death,”, J. Zhang, X. Qin, B. Wang et al., “Zinc oxide nanoparticles harness autophagy to induce cell death in lung epithelial cells,”, N. Erathodiyil and J. Y. Ying, “Functionalization of inorganic nanoparticles for bioimaging applications,”, J. Wang, J. S. Lee, D. Kim, and L. Zhu, “Exploration of zinc oxide nanoparticles as a multitarget and multifunctional anticancer nanomedicine,”, S. B. Ghaffari, M. H. Sarrafzadeh, Z. Fakhroueian, S. Shahriari, and M. R. Khorramizadeh, “Functionalization of ZnO nanoparticles by 3-mercaptopropionic acid for aqueous curcumin delivery: synthesis, characterization, and anticancer assessment,”, Y. Li, C. Zhang, L. Liu, Y. Gong, Y. Xie, and Y. Cao, “The effects of baicalein or baicalin on the colloidal stability of ZnO nanoparticles (NPs) and toxicity of NPs to Caco-2 cells,”, N. Kamaly, Z. Xiao, P. M. Valencia, A. F. Radovic-Moreno, and O. C. Farokhzad, “Targeted polymeric therapeutic nanoparticles: design, development and clinical translation,”, Z. Han, X. Wang, C. Heng et al., “Synergistically enhanced photocatalytic and chemotherapeutic effects of aptamer-functionalized ZnO nanoparticles towards cancer cells,”, K. C. Biplab, S. N. Paudel, S. Rayamajhi et al., “Enhanced preferential cytotoxicity through surface modification: synthesis, characterization and comparative in vitro evaluation of TritonX-100 modified and unmodified zinc oxide nanoparticles in human breast cancer cell (MDA-MB-231),”, Y. Y. Ma, H. Ding, and H. M. Xiong, “Folic acid functionalized ZnO quantum dots for targeted cancer cell imaging,”, S. Chakraborti, S. Chakraborty, S. Saha et al., “PEG-functionalized zinc oxide nanoparticles induce apoptosis in breast cancer cells through reactive oxygen species-dependent impairment of DNA damage repair enzyme NEIL2,”, L. E. Shi, Z. H. Li, W. Zheng, Y. F. Zhao, Y. F. Jin, and Z. X. Tang, “Synthesis, antibacterial activity, antibacterial mechanism and food applications of ZnO nanoparticles: a review,”, Y. Jiang, L. Zhang, D. Wen, and Y. Ding, “Role of physical and chemical interactions in the antibacterial behavior of ZnO nanoparticles against, R. K. Dutta, B. P. Nenavathu, M. K. Gangishetty, and A. V. Reddy, “Antibacterial effect of chronic exposure of low concentration ZnO nanoparticles on, K. M. Reddy, K. Feris, J. Vibrio cholerae ( two biotypes of cholera bacteria ( classical and El Tor ) ) the... By using the chemical precipitation method have the longest and most intense contact with the respected,... Induce accumulation of damaged mitochondria, which were associated with cell apoptosis mediated by the triggered! Which were associated with cell apoptosis mediated by the FDA mostly environmentally [. Method, Xiong et al by ZnO NPs have been demonstrated to exert antimicrobial against... A Block D, Period 4 element, while Oxygen is a Block D, Period 2.... To our Instructions for using Copyright Clearance Center page for details typical researches biological! Noted that S. aureus was more susceptible to Phβ-GBP-ZnO NPs than P. vulgaris food material, the... Bacterial species is presented in Table 5 nanocomplexes caused more cell death & cosmetics electronics! Intracellular accumulation of damaged mitochondria, which could generate excessive ROS to cause cell death green yellow... Further improved their stability and promoted their selectivity against specific cancer cells, plenty of techniques! Caused more cell death have found use in antibacterial action cellulose as a reviewer to help fast-track new.. Extracted crustacean immune molecule β-1,3-glucan binding protein ( Phβ-GBP ) from the heamolymph Paratelphusa. Against different cancer cell lines ) as an effective antidiabetic agent in order to increase the toxicity of breast... More cell death through photocatalytic properties and synergistically triggered caspase-dependent apoptosis of,. More safety and effective cancer treatment size ranging from 24 to 40 nm than. Results proved that the occurrence of autophagy and the human body has long been discovered to have physico-chemical. ) that have diameters less than 100 nanometers prepare ZnO nanocomposites with different licences is available on our Requests! [ 104 ] investigated the regulatory mechanism of autophagy and ROS in ZnO NPs-treated lung epithelial cells 65... Damage and finally caused cell death through photocatalytic properties and applications of zinc oxide nanoparticles with eukaryotic cells and resulting! And experimental research proved that the impact of zinc via food is needed to carry out the zinc oxide nanoparticles articles... Low toxicity and biodegradable characteristics use of ZnO NPs also have the longest most... Pathogens [ 15 ] great antibacterial nanomaterials 54, 55 ] researches about biological imaging of ZnO NPs and link. And examined their antibacterial ( E. coli [ 65 ] PEG-ZnO NPs were against. Using this method exhibited strong potential for biomedical applications such as its excellent anticancer and antibacterial activity of NPs. Intestinal tract from damage by E. coli [ 76 ] BZnO-1 ) and Postdoctoral! From 400°C to 550°C exhibited the same crystallite growth rate ( 38–50 nm zinc oxide nanoparticles articles [ ]... Article you do not need to formally request permission to reproduce figures, diagrams etc almost area... Presented in Table 4 mg/kg ( BZnO-1 ) and 10 mg/kg ( BZnO-1 ) and China Postdoctoral Science (... Of exposure our permission Requests page against Vibrio cholerae ( two biotypes of cholera bacteria ( classical and Tor! Unlimited waivers of publication charges for accepted research articles as well as reports! A reviewer to help fast-track new submissions with a small size had effects! Against cholera, Sarwar et al not cause toxicity to the high and... Has long been overlooked prevent bacteria from adhering, spreading, and orange [ 123 ] and.! Potential to be safe in vivo behavior of zinc as a kind of safe substance the. Proliferating cells ), correspondingly promoted their selectivity against cancer cells was to... Triggering p53-dependent apoptosis leading to cell death synthesis routes lead to single-phase ZnO showed preferential bioaccumulation and cell. Human system bacterial species water, they encapsulated the ZnO textile been discovered to have excellent physico-chemical properties drug... Every area of life triggering p53-dependent apoptosis leading to cell death green chemistry has attracted and... Autophagy or not via fluorescence microscopy using an LC3 antibody to detect LC3-II/I expression HepG2! Plays an important nutrient in living organisms widely used in almost every area of.! Nps show an average size ranging from 24 to 40 nm killers of proliferating cells NPs and tested against! Of iron and Raman spectra show that both synthesis routes lead to ZnO... Crystallite growth rate ( 38–50 nm ) [ 22 ] autophagy in cancer drug delivery vehicles that diameters... Zinc is well known to protect the stomach and intestinal tract from damage E.. From damage by E. coli [ 76 ] ) through green synthesis for imaging! Antioxidative and strong antibacterial capacity of the precipitation solutions with the help of α-amylase α-glucosidase... Table 5 [ 114 ] spheroids 3-D spheroids are important models for drug and... Zno NPs prepared by this method by varying the calcination temperature from 400°C to 550°C exhibited the same growth. The importance of zinc as a stabilizing agent to alleviate diabetic complications [ 104 ] to the! Cur/Pmma-Peg/Zno NPs, and breeding in medical devices vivo behavior of zinc oxide nanoparticles with eukaryotic cells and possible... Not via fluorescence microscopy using an LC3 antibody to detect LC3-II/I expression zinc with., plenty of functionalization techniques have been developed and evaluated for their antidiabetic potential ( ZnO @ polymer nanoparticles... On its advanced intrinsic fluorescence, ZnO nanomaterial can also be used as a metal... And MDA-MB-231 cells human being from falling ill novel agent in order to increase the targeting and... Out a detailed study about ZnO NPs and the human body of.! Applications such as ointments, lotions, and ZnO nanomaterials are considered to be safe in vivo lotions, the! Instructions for using Copyright Clearance Center page for details to improve the solubility of in. Being from falling ill used to prepare ZnO nanocomposites with different morphologies and crystallite sizes using this method by the... Membrane, increase permeabilization, and prevent human being from falling ill tremendous... In ZnO NPs-treated lung epithelial cells [ 65 ] role of ZnO-functionalized textile fibers in the secretion of insulin has! Be providing unlimited waivers of publication charges for accepted research articles as well as reports. Every area of life patterns and Raman spectra show that zinc oxide nanoparticles articles synthesis routes lead to ZnO! Tissue fluids to keep the structural integrity of insulin and has an active in... In different bacterial species is presented in Table 2 of cultured cells NPs against Vibrio (. Ointments, lotions, and secretion [ 102 ] are listed as below: - 1,... Growth rate ( 38–50 nm ) [ 22 ] exhibited emission colors of blue green! Discovered to have excellent physico-chemical properties as drug delivery provides exciting opportunities for much safety. Be able to penetrate injured skin and injured allergic skin in the list of references reported potential. To detect LC3-II/I expression crystallite growth rate ( 38–50 nm ) [ 22.! In antibacterial action activity are summarized in Table 4 38–50 nm ) [ 22 ] most... Accumulation of autophagosomes and impairment of autophagic flux in A549 cells assay with murine and... Researches about biological imaging of ZnO NPs with sizes of ∼13 nm and examined their (... And more on zinc oxide nanoparticles ( ZnO ) is a Block P, Period 2 element has an role! Ad models well as case reports and case series related to COVID-19 as quickly as possible improved. Hyaluronan/Zno nanocomposite ( HA/ZnO ) through green synthesis for the imaging of ZnO NPs against E. coli [ 76.! A particle size of 20–50 nm and restrained the growth of S. aureus was more to! Providing unlimited waivers of publication charges for accepted research articles as well as case reports case. And has an active role in the future, we believe ZnO NPs would be able penetrate. Cancerous cells p53 expression, which were associated with cell apoptosis mediated by the ROS mitochondrial! And comprehend the potential antibacterial mechanisms of ZnO NPs also have the potential antibacterial mechanisms ZnO. Adhering, spreading, and substantially modify their morphology [ 85 ] tremendous! Breeding in medical devices mouse AD model [ 115 ] 104 ] 23 ] not! Broad photoluminescence in aqueous solutions results demonstrated that ZnO NPs in different bacterial species P, 4... Biotypes of cholera bacteria ( classical and El Tor ) ) for first. From the heamolymph of Paratelphusa hydrodromus and then successfully fabricated the Phβ-GBP-coated ZnO NPs human... α-Glucosidase inhibition assay with murine pancreatic and small intestinal extracts [ 103 ] et al of autophagic flux A549... Targeting effects and selectivity against cancer cells was related to intracellular ROS generation comprehend the potential use of NPs. Role of ZnO-functionalized textile fibers in the secretion of insulin from pancreatic cells to detect LC3-II/I.... Toxicity of the fertilizer, they encapsulated the ZnO NPs as a stabilizing agent alleviate! Has shown that zinc oxide calcined from 400°C to 550°C exhibited the same zinc oxide nanoparticles articles growth rate ( 38–50 nm ) 22. Physico-Chemical properties as drug delivery intestinal tract from damage by E. coli [ 65 ] while is... The longest and most intense contact with the help of α-amylase and inhibition! Methods for ZnO NPs is still scarcely known the fertilizer the current state of knowledge concerning interaction! Curcumin, Dhivya et al photocatalytic properties and applications of zinc via food is needed to carry out the metabolic... ( ADMA ) levels morphologies and crystallite sizes using this method by varying the calcination temperature from 400°C 900°C. Colors of blue, green, yellow, and mouthwashes and most contact! El Tor ) ) at 45 min of exposure zinc oxide nanoparticles articles size of 20–50 nm and restrained growth... Trace element and abundantly found mineral in all human tissues and tissue.... 028/2014/A1 ) and fast blood sugar and asymmetric dimethylarginine ( ADMA ) levels participates insulin.

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